Vaccine Ingredients

vaccine, slow kill

Vaccine Excipient & Media Summary

Excipients Included in U.S. Vaccines, by Vaccine

This table includes not only vaccine ingredients (e.g., adjuvants and preservatives), but also substances used during the manufacturing process, including vaccine-production media, that are removed from the final product and present only in trace quantities.
In addition to the substances listed, most vaccines contain Sodium Chloride (table salt).

Last Updated February 2015

All reasonable efforts have been made to ensure the accuracy of this information, but manufacturers may change product contents before that information is reflected here. If in doubt, check the manufacturer’s package insert.

Appendix B

Vaccine

Contains

Source: Manufacturer’s P.I. Dated

Adenovirus

sucrose, D-mannose, D-fructose, dextrose, potassium phosphate, plasdone C, anhydrous lactose, micro crystalline cellulose, polacrilin potassium, magnesium stearate, cellulose acetate phthalate, alcohol, acetone, castor oil, FD&C Yellow #6 aluminum lake dye, human serum albumin, fetal bovine serum, sodium bicarbonate, human-diploid fibroblast cell cultures (WI-38), Dulbecco’s Modified Eagle’s Medium, monosodium glutamate

March 2011

Anthrax (Biothrax)

aluminum hydroxide, benzethonium chloride, formaldehyde, amino acids, vitamins, inorganic salts and sugars

May 2012

BCG (Tice)

glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, Iron ammonium citrate, lactose

February 2009

DT (Sanofi)

aluminum potassium sulfate, peptone, bovine extract, formaldehyde, thimerosal (trace), modified Mueller and Miller medium, ammonium sulfate

December 2005

DTaP (Daptacel)

aluminum phosphate, formaldehyde, glutaraldehyde, 2-Phenoxyethanol, Stainer-Scholte medium, modified Mueller’s growth medium, modified Mueller-Miller casamino acid medium (without beef heart infusion), dimethyl 1-beta-cyclodextrin, ammonium sulfate

October 2013

DTaP (Infanrix)

formaldehyde, glutaraldehyde, aluminum hydroxide, polysorbate 80, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium

November 2013

DTaP-IPV (Kinrix)

formaldehyde, glutaraldehyde, aluminum hydroxide, Vero (monkey kidney) cells, calf serum, lactalbumin hydrolysate, polysorbate 80, neomycin sulfate, polymyxin B, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium

November 2013

DTaP-HepB-IPV (Pediarix)

formaldehyde, gluteraldehyde, aluminum hydroxide, aluminum phosphate, lactalbumin hydrolysate, polysorbate 80, neomycin sulfate, polymyxin B, yeast protein, calf serum, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium, Vero (monkey kidney) cells

November 2013

DTaP-IPV/Hib (Pentacel)

aluminum phosphate, polysorbate 80, formaldehyde, sucrose, gutaraldehyde, bovine serum albumin, 2-phenoxethanol, neomycin, polymyxin B sulfate, Mueller’s Growth Medium, Mueller-Miller casamino acid medium (without beef heart infusion), Stainer-Scholte medium (modified by the addition of casamino acids and dimethyl-beta- cyclodextrin), MRC-5 (human diploid) cells, CMRL 1969 medium (supplemented with calf serum), ammonium sulfate, and medium 199

October 2013

Hib (ActHIB)

ammonium sulfate, formalin, sucrose, Modified Mueller and Miller medium

January 2014

Hib (Hiberix)

formaldehyde, lactose, semi-synthetic medium

March 2012

Hib (PedvaxHIB)

aluminum hydroxphosphate sulfate, ethanol, enzymes, phenol, detergent, complex fermentation medium

December 2010

Centers for Disease Control and Prevention
Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition

April, 2015

Appendix B-7

B

Vaccine

Contains

Source: Manufacturer’s P.I. Dated

Hib/Hep B (Comvax)

yeast (vaccine contains no detectable yeast DNA), nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, amino acids, formaldehyde, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, sodium borate, phenol, ethanol, enzymes, detergent

December 2010

Hib/Mening. CY (MenHibrix)

tris (trometamol)-HCl, sucrose, formaldehyde, synthetic medium, semi- synthetic medium

2012

Hep A (Havrix)

aluminum hydroxide, amino acid supplement, polysorbate 20, formalin, neomycin sulfate, MRC-5 cellular proteins

December 2013

Hep A (Vaqta)

amorphous aluminum hydroxyphosphate sulfate, bovine albumin, formaldehyde, neomycin, sodium borate, MRC-5 (human diploid) cells

February 2014

Hep B (Engerix-B)

aluminum hydroxide, yeast protein, phosphate buffers, sodium dihydrogen phosphate dihydrate

December 2013

Hep B (Recombivax)

yeast protein, soy peptone, dextrose, amino acids, mineral salts, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, formaldehyde, phosphate buffer

May 2014

Hep A/Hep B (Twinrix)

formalin, yeast protein, aluminum phosphate, aluminum hydroxide, amino acids, phosphate buffer, polysorbate 20, neomycin sulfate, MRC-5 human diploid cells

August 2012

Human Papillomavirus (HPV) (Cerverix)

vitamins, amino acids, lipids, mineral salts, aluminum hydroxide, sodium dihydrogen phosphate dehydrate, 3-O-desacyl-4’ Monophosphoryl lipid A, insect cell, bacterial, and viral protein

November 2013

Human Papillomavirus (HPV) (Gardasil)

yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, L-histidine, polysorbate 80, sodium borate

June 2014

Human Papillomavirus (HPV) (Gardasil 9)

yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, L-histidine, polysorbate 80, sodium borate

December 2014

Influenza (Afluria)

beta-propiolactone, thimerosol (multi-dose vials only), monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, neomycin sulfate, polymyxin B, egg protein, sucrose

December 2013

Influenza (Agriflu)

egg proteins, formaldehyde, polysorbate 80, cetyltrimethylammonium bromide, neomycin sulfate, kanamycin, barium

2013

Influenza (Fluarix) Trivalent and Quadrivalent

octoxynol-10 (Triton X- Į-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, sucrose, phosphate buffer

June 2014

Influenza (Flublok)

monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20, baculovirus and host cell proteins, baculovirus and cellular DNA, Triton X-100, lipids, vitamins, amino acids, mineral salts

March 2014

Influenza (Flucelvax)

Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA, SRO\VRUEDWHFHW\OWULPHWKO\DPPRQLXPEURPLGHȕ-propiolactone, phosphate buffer

March 2014

Influenza (Fluvirin)

nonylphenol ethoxylate, thimerosal (multidose vial–trace only in prefilled syringe), polymyxin, neomycin, beta-propiolactone, egg proteins, phosphate buffer

February 2014

Influenza (Flulaval) Trivalent and Quadrivalent

thimerosal, formaldehyde, sodium deoxycholate, egg proteins, phosphate buffer

February 2013

Influenza (Fluzone: Standard (Trivalent and Quadrivalent), High-Dose, & Intradermal)

formaldehyde, octylphenol ethoxylate (Triton X-100), gelatin (standard trivalent formulation only), thimerosal (multi-dose vial only) , egg protein, phosphate buffers, sucrose

2014

B

Appendix B

Centers for Disease Control and Prevention
Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition April, 2015

Appendix B-8

Appendix B

Vaccine

Contains

Source: Manufacturer’s P.I. Dated

Influenza (FluMist) Quadrivalent

ethylene diamine tetraacetic acid (EDTA), monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, gentamicin sulfate, egg protein

July 2013

Japanese Encephalitis (Ixiaro)

aluminum hydroxide, Vero cells, protamine sulfate, formaldehyde, bovine serum albumin, sodium metabisulphite, sucrose

May 2013

Meningococcal (MCV4- Menactra)

formaldehyde, phosphate buffers, Mueller Hinton agar, Watson Scherp media, Modified Mueller and Miller medium, detergent, alcohol, ammonium sulfate

April 2013

Meningococcal (MCV4- Menveo)

formaldehyde, amino acids, yeast extract, Franz complete medium, CY medium

August 2013

Meningococcal (MPSV4- Menomune)

thimerosal (multi-dose vial only), lactose, Mueller Hinton casein agar, Watson Scherp media, detergent, alcohol

April 2013

Meningococcal (MenB – Bexsero)

aluminum hydroxide, E. coli, histidine, sucrose, deoxycholate, kanomycin

2015

Meningococcal (MenB – Trumenba)

polysorbate 80, histodine, E. coli, fermentation growth media

October 2015

MMR (MMR-II)

Medium 199 (vitamins, amino acids, fetal bovine serum, sucrose, glutamate) , Minimum Essential Medium, phosphate, recombinant human albumin, neomycin, sorbitol, hydrolyzed gelatin, chick embryo cell culture, WI-38 human diploid lung fibroblasts

June 2014

MMRV (ProQuad)

sucrose, hydrolyzed gelatin, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, neomycin, bovine calf serum, chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells

March 2014

Pneumococcal (PCV13 – Prevnar 13)

casamino acids, yeast, ammonium sulfate, Polysorbate 80, succinate buffer, aluminum phosphate, soy peptone broth

January 2014

Pneumococcal (PPSV-23 – Pneumovax)

phenol

May 2014

Polio (IPV – Ipol)

2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, monkey kidney cells, Eagle MEM modified medium, calf serum protein, Medium 199

May 2013

Rabies (Imovax)

Human albumin, neomycin sulfate, phenol red indicator, MRC-5 human diploid cells, beta-propriolactone

April 2013

Rabies (RabAvert)

ȕ-propiolactone, potassium glutamate, chicken protein, egg protein, neomycin, chlortetracycline, amphotericin B, human serum albumin, polygeline (processed bovine gelatin), sodium EDTA, bovine serum

March 2012

Rotavirus (RotaTeq)

sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, vero cells [DNA from porcine circoviruses (PCV) 1 and 2 has been detected in RotaTeq. PCV-1 and PCV-2 are not known to cause disease in humans.]

June 2013

Rotavirus (Rotarix)

amino acids, dextran, sorbitol, sucrose, calcium carbonate, xanthan, Dulbecco’s Modified Eagle Medium (potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D- glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red) [Porcine circovirus type 1 (PCV-1) is present in Rotarix. PCV-1 is not known to cause disease in humans.]

May 2014

Smallpox (Vaccinia – ACAM2000)

human serum albumin, mannitol, neomycin, glycerin, polymyxin B, phenol, Vero cells, HEPES

September 2009

Centers for Disease Control and Prevention
Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition

April, 2015

Appendix B-9

B

 

 

Vaccine

Contains

Source: Manufacturer’s P.I. Dated

Td (Decavac)

aluminum potassium sulfate, peptone, formaldehyde, thimerosal, bovine muscle tissue (US sourced), Mueller and Miller medium, ammonium sulfate

March 2011

Td (Tenivac)

aluminum phosphate, formaldehyde, modified Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate

April 2013

Td (Mass Biologics)

aluminum phosphate, formaldehyde, thimerosal (trace), ammonium phosphate, modified Mueller’s media (containing bovine extracts)

February 2011

Tdap (Adacel)

aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, ammonium sulfate, Stainer-Scholte medium, dimethyl-beta-cyclodextrin, modified Mueller’s growth medium, Mueller-Miller casamino acid medium (without beef heart infusion)

March 2014

Tdap (Boostrix)

formaldehyde, glutaraldehyde, aluminum hydroxide, polysorbate 80 (Tween 80), Latham medium derived from bovine casein, Fenton medium containing a bovine extract, Stainer-Scholte liquid medium

February 2013

Typhoid (inactivated – Typhim Vi)

hexadecyltrimethylammonium bromide, formaldehyde, phenol, polydimethylsiloxane, disodium phosphate, monosodium phosphate, semi-synthetic medium

March 2014

Typhoid (oral – Ty21a)

yeast extract, casein, dextrose, galactose, sucrose, ascorbic acid, amino acids, lactose, magnesium stearate. gelatin

September 2013

Varicella (Varivax)

sucrose, phosphate, glutamate, gelatin, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, sodium phosphate monobasic, potassium chloride, EDTA, residual components of MRC-5 cells including DNA and protein, neomycin, fetal bovine serum, human diploid cell cultures (WI-38), embryonic guinea pig cell cultures, human embryonic lung cultures

March 2014

Yellow Fever (YF-Vax)

sorbitol, gelatin, egg protein

May 2013

Zoster (Shingles – Zostavax)

sucrose, hydrolyzed porcine gelatin, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, neomycin, potassium chloride, residual components of MRC-5 cells including DNA and protein, bovine calf serum

February 2014

Leave a Reply

Your email address will not be published. Required fields are marked *