Genetically-modified mRNA lipid nanoparticles were injected into billions of people even while the biodistribution and pharmacokinetic effects remain unknown in humans.
Pfizer’s partner, the German company BioNTech, published an internal 2,237-page report on its animal experiments.
The report parses phrases, saying things like: there was no “systematic” lipid nanoparticle toxicity detected in the rodents. So, there was toxicity.
In addition, the raw data are not included in the report. Their reference numbers are redacted and, under German law, will be kept secret for 15 years before being destroyed.
Lipids–or fats–naturally constitute cell membranes, regulate cell penetration, store vitamins, aid the production of hormones, and much more.
A nanometre is one-billionth of a metre. Nanoparticles can be organic, like volcanic dust, or human-made, such as carbon tubes. Their dimensions are between one and 100 nanometres.
Since the 1990s, scientists have experimented with modified lipid nanoparticles as a vehicle for novel therapeutics.
The aim is to effectively hide the therapeutics in the lipids, like Trojan horses, so that the body does not reject the therapeutic. Once inside the cell, the therapeutic reproduces and in theory stimulates an immune response.
Messenger RNA (mRNA) mediates between genes and proteins. Antigens are molecules that bind to T-cells and antibodies, and typically trigger an immune response. The Pfizer-BioNTech injectable product is, in theory, an mRNA antigen.
Our bodies are electric. Negatively-charged cell surfaces are called anionic.
mRNA membranes are anionic and thus rejected by cell membranes. The mRNA is thus encased in positively-charged lipid nanoparticles (cationic) that enter the given cell.
As late as mid-2019, just prior to the pandemic, it was understood that“Lipid nanoparticles (LNPs) tend to accumulate in the liver.”
The study noting this important fact added: “the mechanisms that promote delivery to other cell types within the liver microenvironment are poorly understood.”
Yet, we are supposed to believe that Pfizer and BioNTech mastered this mystery within months to deliver a safe product.