Vaccine Ingredients
Vaccine Excipient & Media Summary
Excipients Included in U.S. Vaccines, by Vaccine
This table includes not only vaccine ingredients (e.g., adjuvants and preservatives), but also substances used during the manufacturing process, including vaccine-production media, that are removed from the final product and present only in trace quantities.
In addition to the substances listed, most vaccines contain Sodium Chloride (table salt).
Last Updated February 2015
All reasonable efforts have been made to ensure the accuracy of this information, but manufacturers may change product contents before that information is reflected here. If in doubt, check the manufacturer’s package insert.
Appendix B
|
Vaccine |
Contains |
Source: Manufacturer’s P.I. Dated |
|
Adenovirus |
sucrose, D-mannose, D-fructose, dextrose, potassium phosphate, plasdone C, anhydrous lactose, micro crystalline cellulose, polacrilin potassium, magnesium stearate, cellulose acetate phthalate, alcohol, acetone, castor oil, FD&C Yellow #6 aluminum lake dye, human serum albumin, fetal bovine serum, sodium bicarbonate, human-diploid fibroblast cell cultures (WI-38), Dulbecco’s Modified Eagle’s Medium, monosodium glutamate |
March 2011 |
|
Anthrax (Biothrax) |
aluminum hydroxide, benzethonium chloride, formaldehyde, amino acids, vitamins, inorganic salts and sugars |
May 2012 |
|
BCG (Tice) |
glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, Iron ammonium citrate, lactose |
February 2009 |
|
DT (Sanofi) |
aluminum potassium sulfate, peptone, bovine extract, formaldehyde, thimerosal (trace), modified Mueller and Miller medium, ammonium sulfate |
December 2005 |
|
DTaP (Daptacel) |
aluminum phosphate, formaldehyde, glutaraldehyde, 2-Phenoxyethanol, Stainer-Scholte medium, modified Mueller’s growth medium, modified Mueller-Miller casamino acid medium (without beef heart infusion), dimethyl 1-beta-cyclodextrin, ammonium sulfate |
October 2013 |
|
DTaP (Infanrix) |
formaldehyde, glutaraldehyde, aluminum hydroxide, polysorbate 80, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium |
November 2013 |
|
DTaP-IPV (Kinrix) |
formaldehyde, glutaraldehyde, aluminum hydroxide, Vero (monkey kidney) cells, calf serum, lactalbumin hydrolysate, polysorbate 80, neomycin sulfate, polymyxin B, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium |
November 2013 |
|
DTaP-HepB-IPV (Pediarix) |
formaldehyde, gluteraldehyde, aluminum hydroxide, aluminum phosphate, lactalbumin hydrolysate, polysorbate 80, neomycin sulfate, polymyxin B, yeast protein, calf serum, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium, Vero (monkey kidney) cells |
November 2013 |
|
DTaP-IPV/Hib (Pentacel) |
aluminum phosphate, polysorbate 80, formaldehyde, sucrose, gutaraldehyde, bovine serum albumin, 2-phenoxethanol, neomycin, polymyxin B sulfate, Mueller’s Growth Medium, Mueller-Miller casamino acid medium (without beef heart infusion), Stainer-Scholte medium (modified by the addition of casamino acids and dimethyl-beta- cyclodextrin), MRC-5 (human diploid) cells, CMRL 1969 medium (supplemented with calf serum), ammonium sulfate, and medium 199 |
October 2013 |
|
Hib (ActHIB) |
ammonium sulfate, formalin, sucrose, Modified Mueller and Miller medium |
January 2014 |
|
Hib (Hiberix) |
formaldehyde, lactose, semi-synthetic medium |
March 2012 |
|
Hib (PedvaxHIB) |
aluminum hydroxphosphate sulfate, ethanol, enzymes, phenol, detergent, complex fermentation medium |
December 2010 |
Centers for Disease Control and Prevention
Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition
April, 2015
Appendix B-7
B
|
Vaccine |
Contains |
Source: Manufacturer’s P.I. Dated |
||
|
Hib/Hep B (Comvax) |
yeast (vaccine contains no detectable yeast DNA), nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, amino acids, formaldehyde, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, sodium borate, phenol, ethanol, enzymes, detergent |
December 2010 |
||
|
Hib/Mening. CY (MenHibrix) |
tris (trometamol)-HCl, sucrose, formaldehyde, synthetic medium, semi- synthetic medium |
2012 |
||
|
Hep A (Havrix) |
aluminum hydroxide, amino acid supplement, polysorbate 20, formalin, neomycin sulfate, MRC-5 cellular proteins |
December 2013 |
||
|
Hep A (Vaqta) |
amorphous aluminum hydroxyphosphate sulfate, bovine albumin, formaldehyde, neomycin, sodium borate, MRC-5 (human diploid) cells |
February 2014 |
||
|
Hep B (Engerix-B) |
aluminum hydroxide, yeast protein, phosphate buffers, sodium dihydrogen phosphate dihydrate |
December 2013 |
||
|
Hep B (Recombivax) |
yeast protein, soy peptone, dextrose, amino acids, mineral salts, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, formaldehyde, phosphate buffer |
May 2014 |
||
|
Hep A/Hep B (Twinrix) |
formalin, yeast protein, aluminum phosphate, aluminum hydroxide, amino acids, phosphate buffer, polysorbate 20, neomycin sulfate, MRC-5 human diploid cells |
August 2012 |
||
|
Human Papillomavirus (HPV) (Cerverix) |
vitamins, amino acids, lipids, mineral salts, aluminum hydroxide, sodium dihydrogen phosphate dehydrate, 3-O-desacyl-4’ Monophosphoryl lipid A, insect cell, bacterial, and viral protein |
November 2013 |
||
|
Human Papillomavirus (HPV) (Gardasil) |
yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, L-histidine, polysorbate 80, sodium borate |
June 2014 |
||
|
Human Papillomavirus (HPV) (Gardasil 9) |
yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, L-histidine, polysorbate 80, sodium borate |
December 2014 |
||
|
Influenza (Afluria) |
beta-propiolactone, thimerosol (multi-dose vials only), monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, neomycin sulfate, polymyxin B, egg protein, sucrose |
December 2013 |
||
|
Influenza (Agriflu) |
egg proteins, formaldehyde, polysorbate 80, cetyltrimethylammonium bromide, neomycin sulfate, kanamycin, barium |
2013 |
||
|
Influenza (Fluarix) Trivalent and Quadrivalent |
octoxynol-10 (Triton X- Į-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, sucrose, phosphate buffer |
June 2014 |
||
|
Influenza (Flublok) |
monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20, baculovirus and host cell proteins, baculovirus and cellular DNA, Triton X-100, lipids, vitamins, amino acids, mineral salts |
March 2014 |
||
|
Influenza (Flucelvax) |
Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA, SRO\VRUEDWHFHW\OWULPHWKO\DPPRQLXPEURPLGHȕ-propiolactone, phosphate buffer |
March 2014 |
||
|
Influenza (Fluvirin) |
nonylphenol ethoxylate, thimerosal (multidose vial–trace only in prefilled syringe), polymyxin, neomycin, beta-propiolactone, egg proteins, phosphate buffer |
February 2014 |
||
|
Influenza (Flulaval) Trivalent and Quadrivalent |
thimerosal, formaldehyde, sodium deoxycholate, egg proteins, phosphate buffer |
February 2013 |
||
|
Influenza (Fluzone: Standard (Trivalent and Quadrivalent), High-Dose, & Intradermal) |
formaldehyde, octylphenol ethoxylate (Triton X-100), gelatin (standard trivalent formulation only), thimerosal (multi-dose vial only) , egg protein, phosphate buffers, sucrose |
2014 |
||
B
Appendix B
Centers for Disease Control and Prevention
Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition April, 2015
Appendix B-8
Appendix B
|
Vaccine |
Contains |
Source: Manufacturer’s P.I. Dated |
|
Influenza (FluMist) Quadrivalent |
ethylene diamine tetraacetic acid (EDTA), monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, gentamicin sulfate, egg protein |
July 2013 |
|
Japanese Encephalitis (Ixiaro) |
aluminum hydroxide, Vero cells, protamine sulfate, formaldehyde, bovine serum albumin, sodium metabisulphite, sucrose |
May 2013 |
|
Meningococcal (MCV4- Menactra) |
formaldehyde, phosphate buffers, Mueller Hinton agar, Watson Scherp media, Modified Mueller and Miller medium, detergent, alcohol, ammonium sulfate |
April 2013 |
|
Meningococcal (MCV4- Menveo) |
formaldehyde, amino acids, yeast extract, Franz complete medium, CY medium |
August 2013 |
|
Meningococcal (MPSV4- Menomune) |
thimerosal (multi-dose vial only), lactose, Mueller Hinton casein agar, Watson Scherp media, detergent, alcohol |
April 2013 |
|
Meningococcal (MenB – Bexsero) |
aluminum hydroxide, E. coli, histidine, sucrose, deoxycholate, kanomycin |
2015 |
|
Meningococcal (MenB – Trumenba) |
polysorbate 80, histodine, E. coli, fermentation growth media |
October 2015 |
|
MMR (MMR-II) |
Medium 199 (vitamins, amino acids, fetal bovine serum, sucrose, glutamate) , Minimum Essential Medium, phosphate, recombinant human albumin, neomycin, sorbitol, hydrolyzed gelatin, chick embryo cell culture, WI-38 human diploid lung fibroblasts |
June 2014 |
|
MMRV (ProQuad) |
sucrose, hydrolyzed gelatin, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, neomycin, bovine calf serum, chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells |
March 2014 |
|
Pneumococcal (PCV13 – Prevnar 13) |
casamino acids, yeast, ammonium sulfate, Polysorbate 80, succinate buffer, aluminum phosphate, soy peptone broth |
January 2014 |
|
Pneumococcal (PPSV-23 – Pneumovax) |
phenol |
May 2014 |
|
Polio (IPV – Ipol) |
2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, monkey kidney cells, Eagle MEM modified medium, calf serum protein, Medium 199 |
May 2013 |
|
Rabies (Imovax) |
Human albumin, neomycin sulfate, phenol red indicator, MRC-5 human diploid cells, beta-propriolactone |
April 2013 |
|
Rabies (RabAvert) |
ȕ-propiolactone, potassium glutamate, chicken protein, egg protein, neomycin, chlortetracycline, amphotericin B, human serum albumin, polygeline (processed bovine gelatin), sodium EDTA, bovine serum |
March 2012 |
|
Rotavirus (RotaTeq) |
sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, vero cells [DNA from porcine circoviruses (PCV) 1 and 2 has been detected in RotaTeq. PCV-1 and PCV-2 are not known to cause disease in humans.] |
June 2013 |
|
Rotavirus (Rotarix) |
amino acids, dextran, sorbitol, sucrose, calcium carbonate, xanthan, Dulbecco’s Modified Eagle Medium (potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D- glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red) [Porcine circovirus type 1 (PCV-1) is present in Rotarix. PCV-1 is not known to cause disease in humans.] |
May 2014 |
|
Smallpox (Vaccinia – ACAM2000) |
human serum albumin, mannitol, neomycin, glycerin, polymyxin B, phenol, Vero cells, HEPES |
September 2009 |
Centers for Disease Control and Prevention
Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition
April, 2015
Appendix B-9
B
|
Vaccine |
Contains |
Source: Manufacturer’s P.I. Dated |
||
|
Td (Decavac) |
aluminum potassium sulfate, peptone, formaldehyde, thimerosal, bovine muscle tissue (US sourced), Mueller and Miller medium, ammonium sulfate |
March 2011 |
||
|
Td (Tenivac) |
aluminum phosphate, formaldehyde, modified Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate |
April 2013 |
||
|
Td (Mass Biologics) |
aluminum phosphate, formaldehyde, thimerosal (trace), ammonium phosphate, modified Mueller’s media (containing bovine extracts) |
February 2011 |
||
|
Tdap (Adacel) |
aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, ammonium sulfate, Stainer-Scholte medium, dimethyl-beta-cyclodextrin, modified Mueller’s growth medium, Mueller-Miller casamino acid medium (without beef heart infusion) |
March 2014 |
||
|
Tdap (Boostrix) |
formaldehyde, glutaraldehyde, aluminum hydroxide, polysorbate 80 (Tween 80), Latham medium derived from bovine casein, Fenton medium containing a bovine extract, Stainer-Scholte liquid medium |
February 2013 |
||
|
Typhoid (inactivated – Typhim Vi) |
hexadecyltrimethylammonium bromide, formaldehyde, phenol, polydimethylsiloxane, disodium phosphate, monosodium phosphate, semi-synthetic medium |
March 2014 |
||
|
Typhoid (oral – Ty21a) |
yeast extract, casein, dextrose, galactose, sucrose, ascorbic acid, amino acids, lactose, magnesium stearate. gelatin |
September 2013 |
||
|
Varicella (Varivax) |
sucrose, phosphate, glutamate, gelatin, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, sodium phosphate monobasic, potassium chloride, EDTA, residual components of MRC-5 cells including DNA and protein, neomycin, fetal bovine serum, human diploid cell cultures (WI-38), embryonic guinea pig cell cultures, human embryonic lung cultures |
March 2014 |
||
|
Yellow Fever (YF-Vax) |
sorbitol, gelatin, egg protein |
May 2013 |
||
|
Zoster (Shingles – Zostavax) |
sucrose, hydrolyzed porcine gelatin, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, neomycin, potassium chloride, residual components of MRC-5 cells including DNA and protein, bovine calf serum |
February 2014 |
||
