SARS-CoV-2 and ‘gain of function’ research
So a ‘gain of function’ simply means that you take a virus and you change it in some way so it does something new, so it does something that it didn’t do before. That’s all that means. It’s quite simple. So you could for example take this H7N9 virus and make it resistant to an anti-viral drug, that would be a gain of function…
So, to really understand how this virus works, and really any other virus, we do gain of function studies all the time. We don’t make a big deal of it, we don’t write letters telling the world that we’re going to do them because that’s not the way science works. Science works by just doing your experiments. We do this because we would like to see what kinds of changes would lead to a gain of function, and what would be the consequences.
So, in the case of this virus, these investigators want to make the virus drug resistant. As you know, there are a couple of anti-virals that you can use if you get influenza – Tamiflu, Relenza – and these investigators want to make the virus resistant. And the reason they want to do that is to see if a drug resistant mutant would have any properties that would make it scarier in people.
So there is really a goal to these experiments. They want to know if you change the virus what might be the consequences for people. And as I said this is done all the time but these virologists decided to tell the world about it.
(My emphasis.) (Full transcript of interview via this link to view comments in context.)
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